Dr. Mahendra Kavdia

Associate Professor
Biomedical Engineering

Office: ENGR 223
Phone: (479) 575-2850
Fax: (479) 575-2846
E-mail: mkavdia@uark.edu
WWW: http://comp.uark.edu/~mkavdia

Education

• B.Tech, Chemical Engineering, Indian Institute of Technology, Delhi, India
• M.Tech, Chemical Engineering, Indian Institute of Technology, Madras, India
• Ph.D., Chemical Engineering, Oklahoma State University, Stillwater, OK

Honors and Awards

• Arthur C. Guyton Award for Excellence in integrative Physiology and Medicine, American Physiological Society, 2008.
• Imhoff Outstanding Researcher Award, College of Engineering, University of Arkansas, 2008.
• National Center, Scientist Development Grant, American Heart Association, 2005-2008.
• Outstanding Researcher Award, Department of Biological Engineering, 2007-2008.
• Outstanding Mentor, Honors College, University of Arkansas, 2007.
• Faculty Mentor for Lemelson-MIT InvenTeams,  Eureka Spring High School EAST, 2006.
• Dr. K. Subba Raju Award for Best Academic Record, Indian Institute of Technology, Madras, 1995.
• Mico-Bosch Prize for Best Project Environmental Pollution Control Techniques, Indian Institute of Technology, Madras, 1995.

Positions Available

Post Doctoral Associates

Teaching and Research

Research Expertise

• Vascular Systems Biology and Bioengineering
• Computational and Multiscale Modeling of Biological and Physiological Systems
• Biotransport; Signal Transduction and reaction network
• Nitric oxide, Reactive Oxygen and Reactive Nitrogen Species; Oxidative and Nitrosative Stress
• Endothelial Cell Dysfunction; Blood Substitutes
• Mechanisms of Cardiovascular Disease, Diabetes and Age-related Vascular Complications

Research Projects

• Nitric Oxide-Superoxide Interactions in Endothelial Cell Dysfunction. NIH  (R01-HL084337)
• Red Blood Cell Function in Nitric Oxide Biotransport. NIH  (R15-HL087287)
• Nitric oxide transport in the microcirculation. AHA National SDG  (0530050N)

NEW UNDERGRADUATE/GRADUATE COURSES DEVELOPED AND TAUGHT

• BENG4203/5263: Biomedical Engineering Principles: (Fall 04, 05, 06, 07, 08, 09)
• BENG5203: Mathematical Modeling of Physiological Systems: (Spring 06, 07, 09)
• BENG 4233/5273: Numerical Methods in Biomedical Engineering: (Spring 08)
• BENG 500V: Advanced Biomedical Engineering: (Fall 06)

Biographical Information

Curriculum Vitae

Selected Publications

 (total 26)

• Kavdia M, Stanfield J, and Lewis RS. Nitric oxide, superoxide, and peroxynitrite effects on the insulin secretion and viability of beta-TC3 cells. Annals of Biomedical Engineering.  28(1): 102-109, 2000.
• Kavdia M, Tsoukias NM, and Popel AS. Model of nitric oxide diffusion in an arteriole: impact of hemoglobin-based blood substitutes. American Journal of Physiology-Heart Circ Physiol. 282(6): H2245-H2253, 2002.
• Kavdia M, Pittman RN, and Popel AS. Theoretical analysis of the effects of blood substitute affinity and cooperativity on organ oxygen transport. Journal of Applied Physiology. 93: 2122-2128, 2002.
• Kavdia M, and Popel AS. Wall Shear Stress Differentially Affects NO level in Arterioles for Volume Expanders & Hb-Based O2 Carriers. Microvascular Research. 66:49-58, 2003.
• Kavdia M, and Popel AS. Venular endothelium derived no can affect paired arteriole: a computational model. American Journal of Physiology. 290(2): H716-H723. 2006.
• Kavdia M. A computational model for free radical transport in the microcirculation. Antioxidants and Redox Signaling. 8: 1103-1111. 2006. (Invited)
  Marwali MR, Hu CP, Mohandas B, Dandapat A, Deonikar P, Chen J, Cawich I, Sawamura T, Kavdia M and Mehta JL. Modulation of ADP-induced platelet activation by aspirin and pravastatin-Role of LOX-1, nitric oxide, oxidative stress and inside-out integrin signaling. Journal of Pharmacology and Experimental Therapeutics. 322(3):1324-1332. 2007.
• Kavdia M and Richardson WJ. A Computational Model of Biochemical Interaction of NO and Reactive Oxygen Species in the Microcirculation. 8th world congress for microcirculation. In Proceedings of the 8th World Congress for Microcirculation 95-100. 2007.
• Chávez MD, Lakshamanan N and Kavdia M. Impact of superoxide dismutase on nitric oxide and peroxynitrite levels in the microcirculation - A computational model. Conf. Proc. of the IEEE Engineering in Medicine and Biology. (1): 1022-1026, 2007.
• Bhise N and Kavdia M. Design of a bioreactor to study the role of red blood cells in the transport of nitric oxide in the microcirculation. Discovery. 8(2): 29-40, 2007.
  Richardson WJ and Kavdia M. A computational model for analysis of uncoupled NO synthase on nitric oxide and superoxide interaction in microcirculation. Discovery. 8(3): 67-76, 2007.
• Kavdia M. Protection against free radicals by microencapsulation.  “The Bioartificial Endocrine Pancreas (BAEP)”, edited by Jean-Pierre Hallé, Paul de Vos and Lawrence Rosenberg.Chapter 15, 299-307, 2009. (Invited book chapter).
• Abraham JK, Yoon H, Chintakuntla R, Kavdia M, and Varadan VK. Nanoelectronic interface for lab-on-a-chip devices. IET Nanobiotechnology. 2(3): 55–61, 2008.
  Strobel A and Kavdia M.  Computational Modeling of Oxidative Stress:  An Analysis of NAD(P)H effects on Nitric Oxide and Superoxide during Hypertension. Inquiry. 9: 83-91, 2008.
• Cloud AN, Kumar S, Kavdia M, Abu-Safe HH, Gordon MH. Protein Adsorption on Low Temperature Alpha Alumina Films for Surgical Instruments. Surface & Coatings Technology.  203(5-7): 913-917, 2008.
• Deonikar P and Kavdia M. Nitric Oxide Interactions with Red Blood Cell Hemoglobin in a Novel Bioreactor.  25th Southern Biomedical Engineering Conference 2009, IFMBE Proceedings, 24(20). Chapter 3, 301–304, 2009.
• Potdar S and Kavdia M.  Nitric Oxide and Peroxynitrite Interactions in High Glucose Exposed Endothelial Cell: NO-Chemiluminescence Measurement and Computational Modeling.  Microvascular Research. 78(2):191-198, 2009.
• Deonikar P and Kavdia M. A Novel Experimental Model for Quantification of Nitric Oxide-Red Blood Cell Interactions.  Annals of Biomedical Engineering. Accepted, Oct, 2009.
• Deonikar P and Kavdia M. Assessing Effects of Extracellular Diffusion Resistance and Membrane Permeability on Nitric Oxide-Red Blood Cells Interactions Using a Novel Bioreactor. Microvascular Research. Accepted 2009. DOI: 10.1016/j.mvr.2009.10.002.